Extracellular pH monitoring for use in closed-loop vagus nerve stimulation
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چکیده
منابع مشابه
Extracellular pH monitoring for use in closed-loop vagus nerve stimulation.
OBJECTIVE Vagal nerve stimulation (VNS) has shown potential benefits for obesity treatment; however, current devices lack physiological feedback, which limit their efficacy. Changes in extracellular pH (pHe) have shown to be correlated with neural activity, but have traditionally been measured with glass microelectrodes, which limit their in vivo applicability. APPROACH Iridium oxide has prev...
متن کاملChanges in extracellular pH during electrical stimulation of isolated rat vagus nerve.
Double-barrelled pH-sensitive micro-electrodes were used to record changes of extracellular pH during repetitive stimulation of isolated rat vagus nerves. It was found that a small initial alkaline shift was followed by a prolonged acidification. The acidification was correlated in time with the poststimulus undershoot of the extracellular K+ activity and with the recovery phase of the nerve co...
متن کاملVagus nerve stimulation therapy
Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other forms of therapeutic brain stimulation, such as electroconvulsive therapy (ECT), t...
متن کاملVagus Nerve Stimulation.
The vagus nerve is a major component of the autonomic nervous system, has an important role in the regulation of metabolic homeostasis, and plays a key role in the neuroendocrine-immune axis to maintain homeostasis through its afferent and efferent pathways. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, including manual or electrical stimulation. Left ce...
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ژورنال
عنوان ژورنال: Journal of Neural Engineering
سال: 2017
ISSN: 1741-2560,1741-2552
DOI: 10.1088/1741-2552/aa8239